Fig. 31. Amino acid compositions of hypothetical proteins, which were generated as proteins with amino acid compositions specified by 20 random numbers and simply selected only by using 6 conditions for formation of globular proteins. This shows that every one of 20 amino acids in proteins have similar abilities for tertiary structure formation of globular proteins. Therefore, it is evident that specific distributions of amino acid compositions in M. tuberculosis and E. coli proteins as seen in Figs. 29 and 30, have been determined during evolutionary processes of proteins from ancestor proteins encoded by GC-rich genes.