Fig. 29. As seen in the results of Fig. 28, where the simulation was carried out under the condition without any conserved region among evolved proteins, guanine composition at the first codon position was largely deviated from the line drawn by using seven microbial genome data. On the other hand, it is well known that homologous proteins have usually about 40% of conserved regions. Thus, in this Figure, the simulation was carried out by using a M. tuberculosis gene (sense sequence) as an ancestor gene under the condition with 40% conserved regions. From the results, it was confirmed that G1 composition was coincident with the line better, as the ratio of conserved regions increase from 0 to 40%.